The research, which revealed that antidepressants also cause antibiotic resistance, which is described as a global public health threat by the World Health Organization, was published in Archives of Microbiology, one of the world's respected peer-reviewed journals in the field of microbiology. According to the research results; It was shown that sensitive test bacteria exposed to antidepressant active substances fluoxetine, sertraline and amitriptyline developed resistance to some antibiotics. It has been demonstrated that antidepressants can be a direct or indirect cause of antibiotic resistance.